Rab5 Mediates Caspase-8–promoted Cell Motility and Metastasis
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چکیده
منابع مشابه
Rab5 Mediates Caspase-8–promoted Cell Motility and Metastasis
Caspase-8 is a key apical sensory protein that governs cell responses to environmental cues, alternatively promoting apoptosis, proliferation, and cell migration. The proteins responsible for integration of these pathways, however, have remained elusive. Here, we reveal that Rab5 regulates caspase-8-dependent signaling from integrins. Integrin ligation leads to Rab5 activation, association with...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2010
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e09-09-0769